2017
D. Ortiz, B. Tsui, T. Goshia, C.L Chute, A. Han, H. Carter, S.I. Fraley. 3D collagen architecture induces vascular mimicry in cancer cells through a conserved migratory and transcriptional response. (in review)
D. Ortiz, H. Mack, J. Jupe, S. Hawker, N. Kulkarni, B. Hedayatnia, Y. Zhang, S. Lawrence, S. I. Fraley. Massively parallel digital high resolution melt for rapid and absolutely quantitative sequence profiling. Scientific Reports.
2016
S.I. Fraley, P. Athamanolap, B.J. Masek, J. Hardick, K.C. Carroll, Y.-H. Hsieh, R.E. Rothman, C. Gaydos, T.-H. Wang, S. Yang. Nested machine learning algorithm facilitates increased sequence content for large-scale automated High Resolution Melt genotyping. Scientific Reports.
2015
S.I. Fraley, P.-H. Wu, L. He, Y. Feng, R. Krishnamurthy, G.D. Longmore, D. Wirtz. Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions. Scientific Reports.
2014
P. Athamanolap, V. Agarwal, V. Parekh, D.J. Shin, S.I. Fraley, M.A. Jacobs, T.-H. Wang, S. Yang. Trainable High Resolution Melt curve classifier for accurate large-scale genotyping of sequence variants. PLoS ONE.
2013
S.I. Fraley, J. Hardick, B. Masek, P. Athamanolap, R. Rothman, C. Gaydos, K. C. Carroll, T. Wakefield, T.-H. Wang, S. Yang. Universal Digital High Resolution Melt: A novel approach to broad-based profiling of heterogeneous biological samples. Nucleic Acids Research.
The Physical Sciences Oncology Network. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports.
2012
K. Yap, S.I. Fraley, M.M. Thiaville, N. Jinawath, K. Nakayama, J.-L. Wang, T.-L. Want, D. Wirtz, and I.-M. Shih. NAC1 is an actin-binding protein that is essential for effective cytokinesis is cancer cells. Cancer Research.
S.I. Fraley, Y. Feng, G.D. Longmore, & D. Wirtz. Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nature Communications.
2011
C.C. L. Wong, D. Gilkes, H. Zhang, J. Chen, H. Wei, P. Chaturvedi, S.I. Fraley, C. M. Wong, U.-S. Khoo, I.O.L. Ng, D. Wirtz, and G.L. Semenza. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences.
S.I. Fraley, C.M. Hale, R.J. Bloom, A. Celedon, J.S.H. Lee, and D. Wirtz.
Intra- and extracellular microrheology of endothelial cells in a 3D matrix. Biophysical Regulation of Vascular Differentiation and Assembly.
S.I. Fraley, Y. Feng, D. Wirtz, & G. D. Longmore. Reply: reducing background fluorescence reveals adhesions in 3D matrices. Nature Cell Biology.
2010
S.I. Fraley, Y. Feng, R. Krishnamurthy, D.-H. Kim, A. Celedon, G. Longmore, and D. Wirtz. A Distinctive Role for Focal Adhesion Proteins in 3-Dimensional Cell Motility. Nature Cell Biology.
2007
R. Bailey, F. Jones, S.I. Wilson (Fraley), and J. Hiestand. Effects of Packing and Aspect Ratio on Mixing and Heterogeneous Catalysis in Microchannels. 5th Joint ASME/JSME Fluids Engineering Conference.
F. Jones, R. Bailey, Stephanie Wilson, and J. Hiestand. The Effects of Engineering Design on Heterogeneous Biocatalysis in Microchannels. Applied Biochemistry and Biotechnology.
D. Ortiz, B. Tsui, T. Goshia, C.L Chute, A. Han, H. Carter, S.I. Fraley. 3D collagen architecture induces vascular mimicry in cancer cells through a conserved migratory and transcriptional response. (in review)
D. Ortiz, H. Mack, J. Jupe, S. Hawker, N. Kulkarni, B. Hedayatnia, Y. Zhang, S. Lawrence, S. I. Fraley. Massively parallel digital high resolution melt for rapid and absolutely quantitative sequence profiling. Scientific Reports.
2016
S.I. Fraley, P. Athamanolap, B.J. Masek, J. Hardick, K.C. Carroll, Y.-H. Hsieh, R.E. Rothman, C. Gaydos, T.-H. Wang, S. Yang. Nested machine learning algorithm facilitates increased sequence content for large-scale automated High Resolution Melt genotyping. Scientific Reports.
2015
S.I. Fraley, P.-H. Wu, L. He, Y. Feng, R. Krishnamurthy, G.D. Longmore, D. Wirtz. Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions. Scientific Reports.
2014
P. Athamanolap, V. Agarwal, V. Parekh, D.J. Shin, S.I. Fraley, M.A. Jacobs, T.-H. Wang, S. Yang. Trainable High Resolution Melt curve classifier for accurate large-scale genotyping of sequence variants. PLoS ONE.
2013
S.I. Fraley, J. Hardick, B. Masek, P. Athamanolap, R. Rothman, C. Gaydos, K. C. Carroll, T. Wakefield, T.-H. Wang, S. Yang. Universal Digital High Resolution Melt: A novel approach to broad-based profiling of heterogeneous biological samples. Nucleic Acids Research.
The Physical Sciences Oncology Network. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports.
2012
K. Yap, S.I. Fraley, M.M. Thiaville, N. Jinawath, K. Nakayama, J.-L. Wang, T.-L. Want, D. Wirtz, and I.-M. Shih. NAC1 is an actin-binding protein that is essential for effective cytokinesis is cancer cells. Cancer Research.
S.I. Fraley, Y. Feng, G.D. Longmore, & D. Wirtz. Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nature Communications.
2011
C.C. L. Wong, D. Gilkes, H. Zhang, J. Chen, H. Wei, P. Chaturvedi, S.I. Fraley, C. M. Wong, U.-S. Khoo, I.O.L. Ng, D. Wirtz, and G.L. Semenza. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences.
S.I. Fraley, C.M. Hale, R.J. Bloom, A. Celedon, J.S.H. Lee, and D. Wirtz.
Intra- and extracellular microrheology of endothelial cells in a 3D matrix. Biophysical Regulation of Vascular Differentiation and Assembly.
S.I. Fraley, Y. Feng, D. Wirtz, & G. D. Longmore. Reply: reducing background fluorescence reveals adhesions in 3D matrices. Nature Cell Biology.
2010
S.I. Fraley, Y. Feng, R. Krishnamurthy, D.-H. Kim, A. Celedon, G. Longmore, and D. Wirtz. A Distinctive Role for Focal Adhesion Proteins in 3-Dimensional Cell Motility. Nature Cell Biology.
2007
R. Bailey, F. Jones, S.I. Wilson (Fraley), and J. Hiestand. Effects of Packing and Aspect Ratio on Mixing and Heterogeneous Catalysis in Microchannels. 5th Joint ASME/JSME Fluids Engineering Conference.
F. Jones, R. Bailey, Stephanie Wilson, and J. Hiestand. The Effects of Engineering Design on Heterogeneous Biocatalysis in Microchannels. Applied Biochemistry and Biotechnology.